Thermo Fisher Scientific IGSF6 Polyclonal Antibody

Thermo Fisher Scientific IGSF6 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 1:5–1:20
Publications: -

Product Specifications

Product Specific Information

The antibody detects endogenous levels of total IGSF6 protein.

Target Information

IGSF6 (DORA) is a novel member of the immunoglobulin superfamily (IGSF) from human and rat, expressed in dendritic and myeloid cells. Using a probe from the open reading frame of the rat cDNA, a cosmid containing the entire mouse gene was isolated. Comparative analysis and RT-PCR defined the intron/exon structure and mRNA of the mouse gene, as well as the human gene using BAC clones.

The genes span 10 kb (mouse) and 12 kb (human), with six exons arranged similarly to other IGSF members, following the GT-AG rule. Expression of the mouse Igsf6 gene is restricted to immune system cells, particularly macrophages. Northern blot revealed a single mRNA of 2.5 kb in mouse, while the human gene expresses two mRNAs of 1 and 2.5 kb. Both genes are localized to a locus associated with inflammatory bowel disease. The Igsf6 gene is encoded entirely within an intron of an unrelated gene transcribed from the opposite strand, an organization identical in human.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.