Thermo Fisher Scientific KLF15 Polyclonal Antibody
KLF15 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며 IHC(P) 등 다양한 응용 가능. 고순도 항원 친화 크로마토그래피 정제, 액상 형태로 제공. -20°C 보관, 연구용으로 적합.
- 카탈로그번호
- PA550232
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the N-terminal of human Kruppel-like factor 15 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635685 |
Product Specific Information
This antibody detects endogenous levels of total KLF15 protein.
Target Information
KLF15 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. It acts as a transcriptional activator, binding to the GA element of the CLCNKA promoter to regulate tissue- and nephron segment-specific expression of CLCNKA and CLCNKB channel genes.
KLF15 plays a critical role in adipogenesis through regulation of PPARG expression, inhibits cardiac hypertrophy, and participates in pathways regulating cardiac responses to hemodynamic stress. It also controls mitochondrial acetyl-CoA synthase expression in skeletal muscle and may repress rhodopsin and IRBP promoters in the retina, influencing photoreceptor-specific gene expression.
Highly expressed in liver, followed by heart, skeletal muscle, and kidney; not detected in bone marrow or lymphoid tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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