Thermo Fisher Scientific GRP94 Polyclonal Antibody
GRP94 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 최적화되어 있습니다. 인간, 마우스, 랫, 영장류 시료에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 세포 내 단백질 샤페론 연구 및 면역학 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the sequence surrounding Met622 of human GRP94 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979141 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
GRP94 is an 803 amino acid protein belonging to the heat shock protein 90 family. It functions as a molecular chaperone involved in the processing and transport of secreted proteins.
GRP94 and its N-terminal fragment stimulate CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC).
It plays a central role in both innate and acquired immunity, including dendritic cell maturation and chemotaxis, antibody production, and cross-priming.
GRP94 is considered a potential marker in breast cancer and acts as a peptide acceptor in the endoplasmic reticulum, aiding peptide loading of MHC class I molecules.
Expression of GRP94 suppresses A23187-induced apoptosis and stabilizes calcium homeostasis. It is expressed in melanoma, liver metastases of colon carcinoma cells, and human gastric carcinoma BGC-823 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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