Thermo Fisher Scientific VISTA/GI24 (Negative Regulator of Immune Response) Monoclonal Antibody (VISTA/2864)
VISTA 단백질을 표적으로 하는 인간 반응성 마우스 단클론 항체로, ELISA 및 Peptide Array에 사용 가능. 단백질 A/G로 정제된 1 mg/mL 액상 형태이며, 보존제 없음. 면역반응 음성 조절 연구 및 암 면역치료 타깃 연구용.
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Applications
- ELISA (ELISA): Assay-dependent
- Peptide Array (Array): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VISTA/2864 |
| Immunogen | Recombinant full-length human VISTA protein (UniProt ID: Q9H7M9-1, amino acids 1–311) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is encoded by the VSIR gene. Although VISTA shares sequence homology with PD-L1, it exhibits a distinct expression pattern.
In both mice and humans, VISTA is predominantly expressed on hematopoietic cells, with the highest levels on myeloid cells and lower levels on T cells, while being largely absent on B cells.
VISTA expressed by antigen-presenting cells can directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it an important target for cancer immunotherapy.
Reported ligands of VISTA include CD28H, VSIG-3, and VSIG-8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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