Thermo Fisher Scientific ATF4 Monoclonal Antibody ([N360A/24), APC

Applications and Tested Dilution

Product Specifications

Product Specific Information

• 86% identical to rat, and 85% identical to mouse.
• <50% identity with ATF5.
• 1 µg/mL of MA5-45647 was sufficient for detection of ATF4 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Detects approximately 60 kDa.
• Does not cross-react with ATF5.
• This antibody was formerly sold as clone S360A-24.

Target Information

The ATF4 gene encodes a transcription factor originally identified as a mammalian DNA-binding protein capable of binding a tax-responsive enhancer element in the LTR of HTLV-1. It is also known as cAMP-response element binding protein 2 (CREB-2).
This protein belongs to the CREB/AP-1 family of DNA-binding transcription factors, characterized by a C-terminal leucine zipper region for protein-protein interactions and a basic DNA-binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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