Thermo Fisher Scientific KIR3DL1 Monoclonal Antibody (6D9F6)
인간, 비인간 영장류, 랫트 반응성의 KIR3DL1 단일클론 항체. Western blot, IHC, ELISA에 적합하며, Protein G 정제 및 PBS 버퍼에 0.05% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- MA531788
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| ELISA | 1:10,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D9F6 |
| Immunogen | Purified recombinant fragment of human KIR3DL1 (AA: extra 22–340) expressed in Hek293 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787411 |
Product Specific Information
MA5-31788 has been tested in indirect ELISA.
Target Information
KIR3DL1 (Killer cell immunoglobulin-like receptor 3DL1) belongs to a family of transmembrane glycoproteins expressed by natural killer cells and subsets of T cells.
KIR genes are polymorphic and highly homologous, located in a cluster on chromosome 19q13.4 within the leukocyte receptor complex (LRC).
The gene content of the KIR cluster varies among haplotypes, although several framework genes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) are present in all haplotypes.
KIR proteins are classified by:
- Number of extracellular immunoglobulin domains (2D or 3D)
- Cytoplasmic domain length (L for long, S for short)
KIR proteins with long cytoplasmic domains transduce inhibitory signals via an immune tyrosine-based inhibitory motif (ITIM), while short forms lack ITIM and instead associate with TYRO protein tyrosine kinase binding protein to transduce activating signals.
Ligands for several KIR proteins are subsets of HLA class I molecules, indicating their critical role in immune response regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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