Thermo Fisher Scientific CD137 (TNFRSF9) Monoclonal Antibody (OTI12F12)
CD137(TNFRSF9) 단백질을 인식하는 Mouse IgG1 단클론 항체. Western blot과 Flow cytometry에 적합. 인체 시료에 반응하며, HEK293T에서 발현된 full-length 재조합 단백질을 면역원으로 사용. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI12F12 |
| Immunogen | Full length human recombinant protein of human TNFRSF9 (NP_001552) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol, 1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling contributes to the survival and clonal expansion of activated and memory T cells, while suppressing myelopoiesis and dendritic cell development. Activation of CD137 induces cytokine release that regulates peripheral monocyte survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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