Thermo Fisher Scientific TET2 Polyclonal Antibody
TET2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, IP, ChIP assay 등에 사용 가능. 인간 시료 반응성. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human TET2. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736698 |
Product Specific Information
- Positive Control: 293T, A431, HeLa, HepG2, DDDDK-human TET2-transfected 293T
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
TET2는 5-메틸시토신(5mC)을 5-하이드록시메틸시토신(5hmC)으로 변환하는 dioxygenase로, DNA 탈메틸화 과정의 핵심 효소입니다.
5hmC를 5-포밀시토신(5fC) 및 5-카복실시토신(5caC)으로 전환하여 시토신 탈메틸화의 첫 단계를 수행합니다.
또한 TET2는 O-GlcNAc transferase (OGT)를 CpG-rich 전사 시작 부위로 유도하여 히스톤 H2B GlcNAcylation을 촉진합니다.
TET2 유전자 변이는 진성적혈구증가증(Polycythemia vera) 및 골수이형성증후군(Myelodysplastic syndrome)과 관련이 있습니다.
⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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