Thermo Fisher Scientific LAMTOR1 Polyclonal Antibody
Thermo Fisher Scientific의 LAMTOR1 Polyclonal Antibody는 인간 및 생쥐 시료에 반응하는 rabbit polyclonal 항체입니다. Western blot과 ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 버퍼에 보관되며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length human LAMTOR1 recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.69 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736079 |
Product Specific Information
- Positive Control: HeLa, SKNSH
- Predicted Reactivity: Mouse (99%), Rat (97%), Rhesus Monkey (100%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Ragulator complex is comprised of three proteins, C11orf59, ROBLD3, and MAPKSP1, which target mTORC1 to lysosomal surfaces. This normal endosomal trafficking is utilized by certain viruses, including coronavirus, which shows increased replication when C11orf59 is interfered with.
C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis.
C11orf59 and PPAR-alpha cooperate to control lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion, and dysregulation of the mTOR pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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