Thermo Fisher Scientific 4-1BB Ligand Recombinant Rabbit Monoclonal Antibody (ARC1963)
인간, 마우스, 랫트 반응성의 재조합 단일클론 항체로 4-1BB Ligand(CD137L) 검출용. Western blot과 ELISA에 최적화. HEK293 발현 시스템 사용, 고순도 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Thermo Fisher Scientific 4-1BB Ligand Recombinant Rabbit Monoclonal Antibody (ARC1963)
Applications and Tested Dilutions
- Western Blot (WB): 1:1,000–1:4,000
- ELISA: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1963 |
| Immunogen | Synthetic peptide corresponding to amino acids 155–254 of human 4-1BBL/CD137L (UniProt P41273) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.98 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897981 |
Product Specific Information
- Positive Samples: HeLa, Raji, SH-SY5Y, Mouse lung, Mouse brain, Rat lung
- Immunogen Sequence:
GEGSGSVSLA LHLQPLRSAA GAAALALTVD LPPASSEARN SAFGFQGRLL HLSAGQRLGV HLHTEARARH AWQLTQGATV LGLFRVTPEI PAGLPSPRSE
Target Information
CD137 ligand (CD137L) is a type II membrane protein and member of the TNF superfamily. It acts as a co-stimulatory molecule expressed on antigen-presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on various cells including inflamed endothelial cells, enhancing monocyte extravasation. Engagement between CD137 and CD137L promotes T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is expressed on most B-cell lymphomas (mantle, follicular, diffuse large B-cell) but absent in Hodgkin and T-cell lymphomas. It is also detected in carcinoma cell lines and implicated in T cell–tumor cell interactions.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: MA5-38063_4-1BBL_CD137L_P41273-1_Rabbit.svg)
(이미지: MA5-38063_4-1BBL_CD137L_P41273-1_Rabbit_PDP.jpeg)
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