Thermo Fisher Scientific CD40 Monoclonal Antibody (UMAB255), UltraMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD40 antigen is a single-chain glycoprotein, a member of the tumor necrosis factor/nerve growth factor superfamily, and homologous to CD30.
It is expressed on B cells (except plasma cells), epithelial cells, carcinomas, and lymphoid dendritic cells.
CD40 plays a critical role in immune and inflammatory responses, including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
AKNA transcription factor regulates CD40 expression, while TNFR2 adaptor protein mediates CD40 signal transduction.
CD40–CD40L interaction is implicated in amyloid-beta-induced microglial activation, an early event in Alzheimer’s disease pathogenesis.
Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
Diseases associated with CD40 dysfunction include Type 3 Hyper-IgM immunodeficiency and CD40 ligand deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.