Thermo Fisher Scientific Phospho-PKC gamma (Thr674) Polyclonal Antibody
PKC gamma 단백질의 Thr674 인산화 부위를 인식하는 rabbit polyclonal antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합하며, 인간, 마우스, 랫트 시료에 반응. 단백질 A로 정제된 고순도 항체로 뇌 및 신경 관련 연구에 유용.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-PKC gamma (Thr674) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human PKC gamma around the phosphorylation site of Thr674 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action, response to extracellular signals, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. Protein kinase C can be activated by calcium and diacylglycerol, phosphorylating a wide variety of protein targets involved in diverse cellular signaling pathways. PKC family members also serve as receptors for phorbol esters, a class of tumor promoters.
PKC gamma is expressed solely in the brain and spinal cord, localized to neurons. It is essential for neuronal functions such as long-term potentiation (LTP) and long-term depression (LTD). Knockout studies in mice suggest involvement in neuropathic pain development, and defects in this protein have been linked to spinocerebellar ataxia-14 (SCA14).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.