Thermo Fisher Scientific c-Cbl Monoclonal Antibody (S.551.7)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Immunoprecipitation (IP)

1:50

-

Product Specifications

Species Reactivity

Human, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

S.551.7

Immunogen

Synthetic peptide corresponding to the sequence of human c-Cbl

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

18.6 µg/mL

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_10978656

Product Specific Information

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with Cbl-b or Cbl-c proteins.

Target Information

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.