Thermo Fisher Scientific c-Cbl Monoclonal Antibody (S.551.7)
Thermo Fisher Scientific의 c-Cbl Monoclonal Antibody (S.551.7)는 인간 및 비인간 영장류에 반응하는 토끼 IgG 단일클론 항체입니다. Western blot과 Immunoprecipitation에 적합하며, Cbl-b 및 Cbl-c 단백질과 교차 반응하지 않습니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunoprecipitation (IP)
- Tested Dilution: 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host/Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S.551.7 |
| Immunogen | Synthetic peptide corresponding to the sequence of human c-Cbl |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 18.6 µg/mL |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_10978656 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with Cbl-b or Cbl-c proteins.
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, whereas other Cbl proteins are ubiquitously expressed.
Cbl-c, like other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation.
Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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