Thermo Fisher Scientific GABBR1 Recombinant Rabbit Monoclonal Antibody (23GB5495)
GABBR1 단백질을 표적으로 하는 재조합 토끼 단클론 항체. Western blot과 유세포분석(Flow cytometry)에 최적화됨. HEK293F 세포에서 발현된 IgG 형식의 항체로, PBS/glycerol 완충액에 보관. GABA B 수용체 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Flow Cytometry (Flow)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB5495 |
| Immunogen | A synthesized peptide derived from human GABA B Receptor 1 (50–110AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium channels, and modulate inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission.
Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating an inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials.
It is implicated in synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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