Thermo Fisher Scientific GART Recombinant Rabbit Monoclonal Antibody (23GB5520)
GART 단백질을 인식하는 토끼 유래 재조합 단클론 항체. Western blot 및 유세포분석에 적합하며, 인간·마우스·랫에서 반응. HEK293F 발현, 친화 크로마토그래피 정제, PBS/glycerol buffer 보존. 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB5520 |
| Immunogen | A synthesized peptide derived from human GART (550–750AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
MERTK is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1, or GAS6.
It regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis).
Ligand binding induces autophosphorylation of MERTK, creating docking sites for downstream signaling molecules such as GRB2 or PLCG2, leading to phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1.
MERTK signaling is involved in macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and retinal pigment epithelium (RPE) phagocytosis.
It also plays an important role in inhibiting Toll-like receptor (TLR)-mediated innate immune responses by activating STAT1, which induces SOCS1 and SOCS3 expression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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