Thermo Fisher Scientific NRG1 (Neuregulin-1) (extracellular) Polyclonal Antibody, Atto 488

Applications

• Immunohistochemistry (IHC): 1:80 dilution

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL double distilled water (DDW), depending on sample size.
• Ships as lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution stable at 4°C for up to 1 week; for longer storage, aliquot and keep at -20°C.
• Avoid multiple freeze-thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Neuregulin 1 (NRG1) is a 44-kDa glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase, promoting tyrosine phosphorylation. NRG1 gene produces multiple isoforms (heregulins, glial growth factors, sensory and motor neuron-derived factors) through alternative splicing. These isoforms differ structurally and are tissue-specific. HRG isoforms contain Ig and EGF-like domains, while GGF isoforms include kringle-like sequences plus Ig and EGF-like domains. SMDF shares only the EGF-like domain. All NRG1 isoforms bind to ERBB family receptors, inducing growth and differentiation of epithelial, neuronal, glial, and other cell types.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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