Thermo Fisher Scientific NRG1 (Neuregulin-1) (extracellular) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW) depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze-thaw cycles. Centrifuge all antibody preparations before use (10,000 × g for 5 min).

Target Information

Neuregulin 1 (NRG1) was originally identified as a 44-kDa glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase tyrosine phosphorylation.
Various isoforms of NRG1 are generated through alternative splicing, including heregulins (HRGs), glial growth factors (GGFs), and sensory and motor neuron-derived factor (SMDF).
These isoforms are tissue-specific and structurally distinct. HRG isoforms contain immunoglobulin (Ig) and EGF-like domains; GGF isoforms include kringle-like, Ig, and EGF-like domains; SMDF shares only the EGF-like domain.
All NRG1 isoforms interact with ERBB family receptors, inducing growth and differentiation of epithelial, neuronal, glial, and other cell types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.