ELK Biotechnology MEK Kinase-3 rabbit pAb
MEK Kinase-3 rabbit pAb는 인간 MAP3K3 유래 합성 펩타이드로 제작된 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적합하며 다양한 세포 신호전달 경로 연구에 활용됩니다. -20°C에서 1년 보관 가능하며 Human 및 Mouse에 반응합니다.
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제품명
MEK Kinase-3 rabbit pAb
제품 개요
MEK Kinase-3 (MAP3K3)는 세포 내 신호전달 경로에서 SAPK 및 ERK 경로를 조절하는 단백질로, 본 항체는 인간 MAP3K3 유래 합성 펩타이드(AA 101-150)를 면역원으로 사용하여 제작된 rabbit polyclonal antibody입니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MEK Kinase-3 rabbit pAb |
| Alternative Names | MAP3K3; MAPKKK3; MEKK3; Mitogen-activated protein kinase kinase kinase 3; MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human MAP3K3 (AA range: 101–150) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 71 kD |
| GeneID (Human) | 4215 |
| Human Swiss-Prot No. | Q99759 |
| Cellular Localization | Cytoplasm, cytosol |
| Species Reactivity | Human; Mouse |
Background
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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