ELK Biotechnology Fibulin-5 rabbit pAb
Fibulin-5 단백질에 특이적인 토끼 다클론 항체로, 인간, 마우스, 랫트 시료에 반응합니다. WB 및 ELISA에 적합하며, 혈관 발달과 탄성섬유 관련 연구에 활용 가능합니다. -20°C에서 1년 보관 가능합니다.
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- ES2344-xxxxx (2개 옵션)
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제품명
Fibulin-5 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | FBLN5; DANCE; Fibulin-5; FIBL-5; Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FBLN5. AA range: 171-220 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| Gene ID (Human) | 10516 |
| Human Swiss-Prot No | Q9UBX5 |
| Cellular Localization | Secreted; extracellular space; extracellular matrix; co-localizes with ELN in elastic fibers |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a secreted extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
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