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ELK Biotechnology MDM2 rabbit pAb
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ELK Biotechnology MDM2 rabbit pAb

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MDM2 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합. 인간, 마우스, 원숭이에 반응. 종양 억제 단백질 p53과 관련된 연구에 활용 가능. -20°C에서 1년 보관 가능.

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pk
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ELK Biotechnology ES2764-100UL MDM2 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES2764-50UL MDM2 rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology MDM2 rabbit pAb

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MDM2 rabbit pAb

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항목 내용
Alternative Names MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2
Applications WB; IHC; IF; ELISA
Recommended Dilutions WB: 1/500–1/2000
IHC: 1/100–1/300
IF: 1/200–1/1000
ELISA: 1/5000
Not yet tested in other applications
Immunogen The antiserum was produced against synthesized peptide derived from internal human MDM2 (AA range: 132–181)
Host Rabbit
Storage -20°C / 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 90 kD
Gene ID (Human) 4193
Human Swiss-Prot No. Q00987
Species Reactivity Human; Mouse; Monkey
Cellular Localization Nucleus, nucleoplasm, cytoplasm, nucleolus. Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in localization of both proteins to the nucleolus. Colocalizes with RASSF1 isoform A in the nucleus.
Background This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in various cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants, many of which may be expressed only in tumor cells. (RefSeq, Jun 2013)

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