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ELK Biotechnology MDM2 rabbit pAb
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MDM2 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합. 인간, 마우스, 원숭이에 반응. 종양 억제 단백질 p53과 관련된 연구에 활용 가능. -20°C에서 1년 보관 가능.
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ELK Biotechnology ES2764-100UL MDM2 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES2764-50UL MDM2 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology MDM2 rabbit pAb
제품명
MDM2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from internal human MDM2 (AA range: 132–181) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 90 kD |
| Gene ID (Human) | 4193 |
| Human Swiss-Prot No. | Q00987 |
| Species Reactivity | Human; Mouse; Monkey |
| Cellular Localization | Nucleus, nucleoplasm, cytoplasm, nucleolus. Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in localization of both proteins to the nucleolus. Colocalizes with RASSF1 isoform A in the nucleus. |
| Background | This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in various cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants, many of which may be expressed only in tumor cells. (RefSeq, Jun 2013) |
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