ELK Biotechnology MAST205 rabbit pAb
MAST205 rabbit pAb는 인간 MAST2 유래 합성 펩타이드로부터 제작된 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며, 세포질 및 세포막 주변 단백질 검출에 적합합니다. 고품질 IgG 항체로 -20°C에서 1년 보관 가능합니다.
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제품명
MAST205 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAST2; KIAA0807; MAST205; Microtubule-associated serine/threonine-protein kinase 2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAST2 (AA range: 1201–1250) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 196 kD |
| Gene ID (Human) | 23139 |
| Human Swiss-Prot No. | Q6P0Q8 |
| Cellular Localization | Cytoplasm, cytoskeleton, cell membrane (peripheral membrane protein, cytoplasmic side). Recruited to the sub-membranous area on interaction with CDHR2. |
| Species Reactivity | Human; Mouse |
Background
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Magnesium.
Function: Appears to link the dystrophin/utrophin network with microtubule filaments via syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation.
PTM: Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination.
Similarity: Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain, 1 PDZ (DHR) domain, and 1 protein kinase domain.
Subcellular location: Recruited to the sub-membranous area on interaction with PC-LKC.
Tissue specificity: Abundant in the testis.
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