ELK Biotechnology LIMK-1/2 rabbit pAb
인간 LIMK1/2 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 세포질 및 핵 내에서 발현되는 LIM 도메인 키나아제 검출에 적합. -20°C에서 1년 보관 가능하며, 1 mg/ml 농도로 제공.
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제품명
LIMK-1/2 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | LIMK1; LIMK; LIM domain kinase 1; LIMK-1; LIMK2; LIM domain kinase 2; LIMK-2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LIMK1/2 (AA range: 481-530) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 72 kD |
| GeneID (Human) | 3984 / 3985 |
| Human Swiss-Prot No | P53667 / P53671 |
| Species Reactivity | Human; Mouse; Rat; Monkey |
세포 내 위치
Cytoplasm, Nucleus, Cytoplasm (cytoskeleton), Cell projection (lamellipodium).
Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner.
배경 정보
There are approximately 40 known eukaryotic LIM proteins, named for their LIM domains. LIM domains are cysteine-rich structures containing two zinc fingers that mediate protein-protein interactions.
LIM kinase-1 and LIM kinase-2 are part of a small subfamily combining two N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of cofilin.
This protein is ubiquitously expressed during development, plays roles in cytoskeletal organization, stimulates axon growth, and may contribute to brain development. LIMK1 hemizygosity is implicated in impaired visuospatial constructive cognition.
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