ELK Biotechnology Ku-80 rabbit pAb
Ku-80 단백질을 인식하는 토끼 폴리클로날 항체로, DNA 이중가닥 절단 복구 연구에 적합. WB, IHC, IF, ELISA 등 다양한 응용 가능. 사람 및 원숭이 시료에 반응. 핵 및 염색체에 주로 위치. -20°C 보관 시 1년 안정.
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ELK Biotechnology Ku-80 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Ku-80 rabbit pAb |
| Alternative Names | XRCC5; G22P2; X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Ku70/80 (AA range: 683–732) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 80 kDa |
| GeneID (Human) | 7520 |
| Human Swiss-Prot No | P13010 |
| Cellular Localization | Nucleus; Nucleolus; Chromosome |
| Species Reactivity | Human; Monkey |
Background
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein, also known as ATP-dependent DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase and functions with the DNA ligase IV–XRCC4 complex in the repair of DNA double-strand breaks by non-homologous end joining and in V(D)J recombination. This gene complements the Chinese hamster xrs-6 mutant defective in DNA double-strand break repair and V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. (RefSeq, Jul 2008)
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