ELK Biotechnology hnRNP K rabbit pAb
인간 hnRNP K 단백질을 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 적합하며 다양한 종(Human, Mouse, Rat)에 반응. 세포 내 핵 및 세포질에서 발현되는 hnRNP K 연구에 유용. -20°C에서 1년 보관 가능.
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제품명
hnRNP K rabbit pAb
제품 개요
이 항체는 인간 hnRNP K 단백질의 합성 펩타이드(AA 250–299)로부터 생성된 토끼 폴리클로날 항체입니다. hnRNP K는 RNA 결합 단백질로, 전사 후 조절 및 세포 주기 진행에 관여합니다.
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | HNRNPK; HNRPK; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; Transformation up-regulated nuclear protein; TUNP |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/40000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human hnRNP K (AA 250–299) |
| Host Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 51 kDa |
| Gene ID (Human) | 3190 |
| Human Swiss-Prot No. | P61978 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, Nucleus (nucleoplasm), Cell projection (podosome). Recruited to p53/TP53-responsive promoters in presence of functional p53/TP53 (PubMed:16360036). Predominantly nuclear in ASFV infection (PubMed:18775702). |
Background
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and influence pre-mRNA processing, mRNA metabolism, and transport. While most hnRNPs are nuclear, some shuttle between the nucleus and cytoplasm. The hnRNP K protein contains three KH domains that bind RNA and has a distinct preference for poly(C). It is also implicated in cell cycle progression. Several alternatively spliced transcript variants have been identified.
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