Thermo Fisher Scientific Phospho-PDE11A (Ser117, Ser124) Polyclonal Antibody
Phospho-PDE11A (Ser117, Ser124) 폴리클로날 항체로, 인간·마우스·랫트 반응성. Western blot, ELISA, IP에 사용 가능. 합성 인산화 펩타이드 면역원으로 제작되었으며, 고순도 친화 크로마토그래피 정제. 연구용으로 신호전달 관련 PDE11A 단백질 분석에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 1:50–1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 100–150 on PDE11A protein. Phosphorylated at Ser117 & Ser124 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The 3’,5’-cyclic nucleotides cAMP and cGMP act as second messengers in diverse signal transduction pathways. 3’,5’-cyclic nucleotide phosphodiesterases (PDEs) hydrolyze cAMP and cGMP to 5’-monophosphates, downregulating cyclic nucleotide signaling. The PDE11A gene encodes a member of the PDE superfamily. Mutations in this gene are associated with Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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