Thermo Fisher Scientific IL-17A Recombinant Mouse Monoclonal Antibody (eBio64DEC17)
Recombinant mouse monoclonal antibody recognizing IL-17A, validated for IHC, ICC/IF, and Flow Cytometry. Offers high specificity and lot-to-lot consistency. Suitable for detecting IL-17A in inflammatory and autoimmune research. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 0.25–2 µg/test |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | eBio64DEC17 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Available Formats
Product Specific Information
Recombinant mouse monoclonal antibodies are produced using in vitro expression systems. Specific genes encoding the desired antibodies are cloned into an expression vector and expressed in vitro.
Advantages include improved specificity and lot-to-lot consistency. It is recommended to titrate the antibody carefully for optimal performance in the intended assay.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in conditions such as rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa disulfide-linked homodimer of 136 amino acids, part of the IL-17A–17F family, signaling through IL-17R/CDw217. It induces IL-6, IL-8, G-CSF, and PGE2 secretion, and supports CD34+ progenitor proliferation and neutrophil maturation.
IL-17A also regulates NF-κB and MAPK pathways, stimulating IL-6 and COX-2 expression and enhancing nitric oxide production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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