Thermo Fisher Scientific GCK Monoclonal Antibody (3C7)
GCK 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제 제품이며, PBS(pH 7.4) 용액 상태로 제공됩니다. 인간 GCK 단백질 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C7 |
| Immunogen | GCK (AAH01890.1, 356 a.a. ~ 465 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GLRPSTTDCD IVRRACESVS TRAAHMCSAG LAGVINRMRE SRSEDVMRIT VGVDGSVYKL HPSFKERFHA SVRRLTPSCE ITFIESEEGS GRGAALVSAV ACKKACMLGQ
Target Information
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, committing glucose to the glycolytic pathway.
Alternative splicing of this gene results in three tissue-specific forms of glucokinase — one in pancreatic islet beta cells and two in liver.
The protein localizes to the outer membrane of mitochondria. Unlike other hexokinases, this enzyme is not inhibited by glucose-6-phosphate and remains active while glucose is abundant.
Mutations in this gene are associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young (MODY2), and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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