Thermo Fisher Scientific Interferon alpha/beta receptor 1 Recombinant Rabbit Monoclonal Antibody (BLR265L)
인간 IFNAR1을 인식하는 재조합 토끼 단클론 항체로, WB, IHC, Flow, IP 등 다양한 응용에 적합합니다. 고순도 정제된 액상 형태로 제공되며, 4°C에서 보관합니다. 세포 신호전달 및 인터페론 연구용으로 권장됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:4,000 |
| Flow Cytometry (Flow) | 1 µL/10^6 cells |
| Immunoprecipitation (IP) | 15 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR265L |
| Immunogen | Recombinant protein representing the extracellular domain of Human Interferon alpha/beta receptor 1 (residues 27–436) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 400 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
Interferons are widely used therapeutic agents due to their antitumor and antiviral effects, as well as their modulatory effects on the immune system (Biron, 2001; Kirkwood, 2002). These cytokines exert their effects by binding to the Type I Interferon Receptor (IFNAR1).
Downregulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling, influenced by phosphorylation of Serine 535 and 539 in IFNAR1 (Kumar et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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