Thermo Fisher Scientific MBD4 Polyclonal Antibody
MBD4 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 30% 글리세롤 버퍼에 보관. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to an internal portion of the human MBD4 protein (between residues 200–250) [UniProt O95243] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.11 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 30% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718836 |
Target Information
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is essential for proper development and gene expression regulation. The methylation pattern involves enzymatic methylation and demethylation. The mammalian demethylation enzyme exhibits demethylase activity associated with a methyl-CpG-binding domain (MBD).
MeCP2 and MBD1 repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) colocalize with heavily methylated satellite DNA and mediate methylation signal functions. MBD3 does not bind methylated DNA. MBD1, MBD2, MBD3, and MBD4 are expressed in somatic tissues, but MBD1 and MBD2 expression is reduced or absent in embryonic stem cells. MBD4 shares homology with bacterial base excision repair DNA N-glycosylases/lyases and is sometimes mutated in microsatellite unstable tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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