Thermo Fisher Scientific Phospho-Sphingosine 1-Phosphate Receptor 1 (Ser358, Ser359) Polyclonal Antibody
인산화된 S1P1 수용체(Ser358, Ser359)를 인식하는 Rabbit Polyclonal 항체. Western blot 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 세포 이동 및 신호전달 연구에 적합.
- 카탈로그번호
- 7TM0275C
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
- Western Blot (WB): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human S1P1 around the phosphorylation site of Ser358/Ser359 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P), coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling activates RAC1, SRC, PTK2/FAK1, and MAP kinases. It plays a critical role in cell migration by reorganizing the actin cytoskeleton and forming lamellipodia in response to stimuli that increase sphingosine kinase SPHK1 activity. S1P1 is essential for normal chemotaxis toward S1P, embryonic heart development, and cardiac morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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