Thermo Fisher Scientific RON Polyclonal Antibody
Thermo Fisher Scientific의 RON Polyclonal Antibody는 Mouse RON 단백질을 인식하는 Rabbit IgG 폴리클로날 항체입니다. Western blot 및 IHC(Paraffin) 검증 완료. 고순도 Protein A 및 항원 친화 크로마토그래피 정제. 연구용으로 세포 증식 및 이동 관련 RON 단백질 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:10–1:50
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between amino acids 1013–1041 from the C-terminal region of mouse Mst1r |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2717732 |
Target Information
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein forms a membrane-spanning, disulfide-linked heterodimer produced by cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding induces tyrosine phosphorylation of the beta chain. Knockout studies show MST1R/RON (-/-) mice fail to survive past the periimplantation period. The MST1R/RON gene maps to 3p21, a region frequently deleted or mutated in small cell lung and renal carcinoma, and is implicated in epithelial cancer progression. Expression of MST1R/RON has been documented in various normal human tissues, including colon, mouth, prostate, and testis, and in cancerous tissues such as colon, prostate, stomach, and uterus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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