Thermo Fisher Scientific TRAF3 Polyclonal Antibody
TRAF3 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. Human 및 Mouse 시료에 반응하며, Protein G로 정제된 액상형 제품입니다. TRAF3 신호전달 연구용으로 높은 특이성과 재현성을 제공합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
| in situ PLA (PLA) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids between 300 and 350 of human TRAF3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2209319 |
Product Specific Information
Suggested positive control: 3T3 whole cell lysate, HeLa or NIH-3T3, antigen standard for TRAF3 (transient overexpression lysate).
Target Information
Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40, etc.) and the interleukin-1 receptor.
The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization.
Recent molecular cloning studies have led to identification of six TRAFs (TRAF1–TRAF6). TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region of similarity to the TNF-alpha receptor-associated factors. TRAF3 binds only a single site containing the sequence PEQET, whereas TRAF1 and TRAF2 can bind to either the PEQET site or an additional downstream domain.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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