Thermo Fisher Scientific TRAF3 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Suggested positive control: 3T3 whole cell lysate, HeLa or NIH-3T3, antigen standard for TRAF3 (transient overexpression lysate).

Target Information

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40, etc.) and the interleukin-1 receptor.
The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization.
Recent molecular cloning studies have led to identification of six TRAFs (TRAF1–TRAF6). TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region of similarity to the TNF-alpha receptor-associated factors. TRAF3 binds only a single site containing the sequence PEQET, whereas TRAF1 and TRAF2 can bind to either the PEQET site or an additional downstream domain.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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