Thermo Fisher Scientific NUMBL Polyclonal Antibody
Rabbit polyclonal antibody against human NUMBL protein for IHC(P) applications. Recombinant immunogen-based, antigen affinity purified, unconjugated liquid form. Suitable for neurogenesis and NF-κB pathway research. For research use only.
- 카탈로그번호
- PA563539
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific NUMBL Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) [IHC (P)]
Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NUMBL. Recombinant protein control fragment (Product #RP-98383) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644888 |
Product Specific Information
- Immunogen sequence:
PTMPPALQPF PAPVGPFDAA PAQVAVFLPP PHMQPPFVPA YPGLGYPPMP - Highest antigen sequence identity:
- Mouse: 88%
- Rat: 86%
Target Information
NUMBL plays a role in neurogenesis and the maintenance of neural progenitor cells (radial glial cells). It is required throughout embryonic neurogenesis for progenitor cell fate determination and postnatally in the subventricular zone (SVZ) for neuroblast survival and ependymal wall integrity.
Acts as a negative regulator of the NF-kappa-B signaling pathway by inhibiting MAP3K7IP2 interaction with polyubiquitin chains of TRAF6 and RIPK1, and promoting Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 상품 관련 이미지는 하단에 배치됩니다.)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.