Thermo Fisher Scientific CYB561D2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total C56D2.

Target Information

CYB561D2 (Cytochrome b561 domain-containing protein 2), also known as putative tumor suppressor protein 101F6, is a 222 amino acid highly hydrophobic protein with six membrane-spanning domains.
Localized to endosomes and endoplasmic reticulum in the perinuclear region, CYB561D2 contains two heme-binding sites that reduce ferric ions.
It is ubiquitously expressed, with highest levels in lung, liver, and kidney. CYB561D2 is abundant in normal lung bronchial epithelial cells but absent in most lung cancers.
The gene encoding CYB561D2 maps to human chromosome 3p21.3, a region prone to genetic alterations and early allele loss in many human cancers.
Exogenous expression of CYB561D2 induces caspase-independent apoptotic and autophagic pathways, synergistically killing tumor cells — suggesting its potential role as a therapeutic target in cancer treatment.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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