Thermo Fisher Scientific Aquaporin 0 Polyclonal Antibody
Aquaporin 0 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 50–150 of human MIP (NP_036196.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.83 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914412 |
Product Specific Information
Positive test controls:
HepG2, U-251MG, Mouse skeletal muscle, Mouse heart, Mouse liver, Mouse testis, Mouse eye, Rat eye.
Subcellular localization:
Cell junction, Cell membrane, Multi-pass membrane protein, Gap junction.
Immunogen sequence:
LALATLVQSV GHISGAHVNP AVTFAFLVGS QMSLLRAFCY MAAQLLGAVA GAAVLYSVTP PAVRGNLALN TLHPAVSVGQ ATTVEIFLTL QFVLCIFATY D
Target Information
AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells. It functions as a water pore and is involved in fiber-fiber adhesion, crucial for lens fiber cell structure and organization.
AQP0 has a unique pore constriction responsible for gating, holding only three water molecules spaced too far apart for hydrogen bonding.
The C-terminal domain undergoes extensive post-translational modifications, including truncations during lens aging, which may contribute to cataract formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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