Thermo Fisher Scientific CDC37 Polyclonal Antibody
CDC37 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, ELISA, IP에 사용 가능. Human 및 Mouse 시료 반응. Affinity Chromatography로 정제된 액상 포맷. 세포질 내 CDC37 검출에 적합. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–160 of human CDC37 (NP_008996.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.63 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914410 |
Product Specific Information
Positive test controls include: Raji, HeLa, HepG2, BT474, HT-1080.
The target is usually found in the following locations: Cytoplasm.
Immunogen sequence:
MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS KDGFSKSMVN TKPEKTEEDS EEVREQKHKT FVEKYEKQIK
Target Information
In S. cerevisiae, Cdc37 is an important regulator of the cell division cycle through its action on cyclin-dependent kinases (CDKs).
Cdc37 is also associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase, and the sevenless receptor tyrosine kinase.
HSP90 has been shown to associate with many of the same cellular targets as Cdc37. Cdc37, also known as p50, forms complexes with Src-family kinases (Fyn, Yes, Fes, Lck, Fgr), Raf, and pp60v-src.
Cdc37 functions as a chaperone both independently and in concert with HSP90 and is essential for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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