Thermo Fisher Scientific F13A1 Monoclonal Antibody (UMAB243), UltraMAB
인간 F13A1(Factor XIIIa)에 특이적인 UMAB243 클론 단일클론 항체로, IHC(P)에서 1:300 희석으로 검증됨. HEK293T에서 생산된 완전 길이 재조합 단백질을 면역원으로 사용. 액상 형태, 0.5–1.0 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific F13A1 Monoclonal Antibody (UMAB243), UltraMAB
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:300 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB243 |
| Immunogen | Full length human recombinant protein of human F13A1 (Factor XIIIa) produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules. Platelet factor XIII consists of two A subunits identical to those of plasma origin. Upon activation by thrombin and calcium ions, plasma factor XIII dissociates its B subunits to yield the active enzyme, factor XIIIa, which acts as a transglutaminase to stabilize fibrin clots through gamma-glutamyl-epsilon-lysine crosslinking. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to fibrin alpha chains. Factor XIII deficiency can lead to bleeding tendency, defective wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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