Thermo Fisher Scientific Human ARHGEF17 Synthetic Peptide
인간 TEM4 단백질 중심부 18개 아미노산 서열로 구성된 합성 펩타이드. ARHGEF17 연구용 차단 펩타이드로 사용 가능. Rho GTPase 신호전달 연구에 적합. 고순도 정제, PBS 완충액에 BSA 포함, -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human TEM4.
PEP-0557 can be used as a blocking peptide with polyclonal antibody PA5-20440.
Target Information
Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks the typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and is predominantly expressed in the heart. It couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7, and TEM7R have been observed in breast cancer tissues. TEM4 could also prove to be a useful therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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