Thermo Fisher Scientific CDKN2A/p14ARF Polyclonal Antibody, Biotin
CDKN2A/p14ARF 단백질을 인식하는 Thermo Fisher Scientific의 Biotin 결합 폴리클로날 항체. Western blot, ELISA, IP에 적합하며 인간, 마우스, 랫트 시료에 반응. 종양 억제 단백질 연구 및 세포주기 조절 연구용으로 사용.
- 카탈로그번호
- P14ARF120BIOTIN
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to C-terminal amino acids 94–111 of Human p14ARF. Sequence: QRLGQQPLPRRPGHDDGQ |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins, p16INK4a and the alternative reading frame protein ARF (p14ARF in human and P19ARF in mouse).
These proteins interact with upstream tumor suppressors (retinoblastoma protein and p53) and play key roles in cellular senescence, cell cycle control, and tumor suppression.
p14ARF (or P19ARF in mouse) can induce both G1 and G2 phase arrest in a p53-dependent manner. Differences in ARF function between human and mouse may contribute to species-specific tumor susceptibility.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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