Thermo Fisher Scientific GTPase HRAS Polyclonal Antibody, Biotin
HRAS 단백질을 표적하는 Biotin 결합 폴리클로날 항체로, WB, IHC, ELISA, IP 등 다양한 응용에 사용 가능. Rabbit IgG 기반으로 높은 특이성과 감도를 제공. 인간, 생쥐, 닭, 랫트 반응성. 연구용으로만 사용.
- 카탈로그번호
- P21RAS121BIOTIN
- 판매단위
- pk
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Thermo Fisher Scientific GTPase HRAS Polyclonal Antibody, Biotin
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 139–189 of human GTPase HRAS protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Monomeric G protein Ras acts as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to downstream signaling pathways that lead to distinct cytoplasmic or nuclear events. Mammalian cells contain three Ras proto-oncogenes coding for closely related Ras proteins: H-, K-, and N-Ras. Oncogenic mutations in Ras genes occur in approximately 30% of human cancers. Constitutive activation of Ras due to mutation or overexpression promotes proliferation and inhibits apoptosis.
- K-Ras mutations: Common in pancreatic, colorectal, and non-small-cell lung carcinomas
- H-Ras mutations: Common in bladder, kidney, and thyroid carcinomas
- N-Ras mutations: Found in melanoma, hematological malignancies, and hepatocellular carcinoma
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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