Thermo Fisher Scientific GTPase HRAS Polyclonal Antibody, Biotin
HRAS 단백질을 표적으로 하는 Biotin 접합 폴리클로날 항체로, Western blot, ELISA, IP에 적합. 인간, 생쥐 등 다양한 종 반응성. 합성 펩타이드 면역원 사용, Affinity chromatography로 정제. 연구용으로만 사용 가능.
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Thermo Fisher Scientific GTPase HRAS Polyclonal Antibody, Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Fruit fly, Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–50 on human GTPase HRAS protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to various downstream signaling pathways, leading to distinct cytoplasmic or nuclear events.
Each mammalian cell contains three Ras proto-oncogenes coding for closely related Ras proteins: H-, K-, and N-Ras. Oncogenic mutations in Ras genes are present in approximately 30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression stimulates proliferation and inhibits apoptosis.
- K-Ras mutations: Common in pancreatic, colorectal, and non–small-cell lung carcinomas
- H-Ras mutations: Common in bladder, kidney, and thyroid carcinomas
- N-Ras mutations: Found in melanoma, hematological malignancies, and hepatocellular carcinoma
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: P21RAS-BIOTIN_H-Ras_P01112-1_Rabbit.svg, P21RAS-BIOTIN_H-Ras_P01112-1_Rabbit_PDP.jpeg)
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배송/결제/교환/반품 안내
배송 정보
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