Thermo Fisher Scientific GTPase HRAS Polyclonal Antibody, FITC
FITC로 표지된 HRAS 단백질에 대한 Rabbit Polyclonal 항체로, Western blot, IHC, ELISA, IP 등 다양한 응용에 적합합니다. Human, Mouse, Rat, Chicken 시료 반응성이 있으며, 형광 스펙트럼은 498/517 nm입니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- P21RAS-121-FITC
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 139–189 on human GTPase HRAS protein |
| Conjugate | FITC (Fluorescein) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to various downstream signaling pathways leading to cytoplasmic or nuclear events. Each mammalian cell contains three Ras proto-oncogenes coding for closely related Ras proteins: H-, K-, and N-Ras. Oncogenic mutations in Ras genes are found in approximately 30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression stimulates proliferation and inhibits apoptosis.
- K-Ras mutations: common in pancreatic, colorectal, and non-small-cell lung carcinomas
- H-Ras mutations: common in bladder, kidney, and thyroid carcinomas
- N-Ras mutations: found in melanoma, hematological malignancies, and hepatocellular carcinoma
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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