Thermo Fisher Scientific CDK2 Monoclonal Antibody (OTI4D3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CDK2/cyclinO is a member of the cyclin-dependent protein kinase family complexed to CyclinO. CyclinO, a specific protein isoform of the UNG gene, is localized exclusively in the nucleus and exhibits significant uracil-DNA glycosylase activity.
CDK2/cyclinO protein levels increase during the G1 phase and are degraded during the cell cycle. Cyclin A–CDK2 levels peak at the G1/S transition, with both proteins associated with DNA in the replication initiation complex.
Rb protein serves as a substrate for CDK2–Cyclin E and/or CDK2–Cyclin A in vivo. CDK2 is activated and localized to the nucleus during late G1, S, and G2 phases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.