Thermo Fisher Scientific JAK2 Monoclonal Antibody (OTI7D12), TrueMAB
인간 JAK2 단백질(aa 297-596)을 인식하는 Mouse IgG2b 단클론 항체로, IHC(P)에서 1:150 희석으로 검증됨. TrueMAB 포맷, 동결건조 형태이며 PBS/trehalose 버퍼에 보존. 세포 신호전달 연구 및 JAK2 관련 질환 연구용으로 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific JAK2 Monoclonal Antibody (OTI7D12), TrueMAB
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7D12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 297–596 of human JAK2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in cytokine receptor signaling and is mutated in polycythemia vera.
This kinase contains the catalytic domain (JH1) of JAK2. Activation of JAKs leads to phosphorylation of STAT proteins, which dimerize and translocate to the nucleus to regulate gene transcription.
JAK2 is essential for IFN gamma-receptor complex initiation, while JAK1 acts as an amplifier.
Mutations in JAK2 are associated with Budd-Chiari syndrome, polycythemia vera, thrombocythemia, myelofibrosis, and acute myelogenous leukemia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.