Thermo Fisher Scientific SIRT1 Recombinant Rabbit Monoclonal Antibody (032)

Applications

ELISA (ELISA)

• Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the rabbit immune repertoire

This antibody is specific for Human SIRT1.

Target Information

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of multiple cellular functions such as cell cycle regulation, DNA damage response, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function through histone deacetylation and promotes changes in histone and DNA methylation, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and mediates inhibitory effects on myoblast differentiation under low-nutrient conditions via AMPK and NAMPT pathways.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.