Thermo Fisher Scientific IDH1 Polyclonal Antibody
Human 및 Mouse 반응성의 IDH1 폴리클로날 항체로 Western blot에 적합. 합성 펩타이드 면역원 사용, 비결합 액상 형태. 0.5 mg/mL 농도, TBS(pH 7.3) 및 BSA 포함. 연구용으로만 사용 가능.
- 카탈로그번호
- PA519413
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EITYTPSDGTQK) corresponding to internal amino acids of IDH1 (aa 153–164) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10989505 |
Product Specific Information
- Predicted to react with canine, rabbit, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:1,000.
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two subclasses: one utilizing NAD(+) and the other NADP(+).
Five isocitrate dehydrogenases have been identified:
- Three NAD(+)-dependent (mitochondrial matrix)
- Two NADP(+)-dependent (one mitochondrial, one cytosolic)
The cytoplasmic NADP(+)-dependent isozyme encoded by this gene is found in cytoplasm and peroxisomes and includes a PTS-1 peroxisomal targeting signal.
It plays roles in NADPH regeneration for intraperoxisomal reductions and reactions consuming 2-oxoglutarate, such as alpha-hydroxylation of phytanic acid.
This enzyme contributes significantly to cytoplasmic NADPH production.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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