Thermo Fisher Scientific Human ASK1 Synthetic Peptide
인간 ASK1 단백질의 C-말단 20개 아미노산 서열로 구성된 합성 펩타이드. 항체 PA5-19880의 블로킹 펩타이드로 사용 가능. 정제된 액상 형태로 PBS, BSA, sodium azide 포함. 연구용으로만 사용.
- 카탈로그번호
- PEP0255
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 20 amino acids near the carboxy terminus of human ASK1.
PEP-0255 can be used as a blocking peptide with polyclonal antibody PA5-19880.
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated in response to various extracellular stimuli including cytokines, growth factors, and environmental stresses.
ASK1 (apoptosis signal-regulating kinase 1, also known as MAPKKK5) activates MAPKKs MKK4 and MKK6, which subsequently activate JNK and p38 MAP kinases, respectively.
ASK1/MAPKKK5 is activated by TNFR and Fas through interactions with TRAF family members and Daxx. Overexpression of ASK1 induces apoptotic cell death, whereas a catalytically inactive form inhibits TNF-α-induced apoptosis. ASK1 is expressed in a variety of human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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