Thermo Fisher Scientific Human STAT1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 39 amino acids near the carboxy terminus of human STAT1 Alpha.
PEP-0256 can be used as a blocking peptide with polyclonal antibody PA5-19858.

Target Information

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. It regulates several genes involved in cell growth, apoptosis, immune responses, and lipid metabolism. STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure.

The STAT1 gene is located on chromosome 2 and is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STAT types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by ligands such as IFN family (IFN-Alpha, IFN-Beta, IFN-gamma, IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF), and receptor tyrosine kinases (EGF, PDGF, CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.