Thermo Fisher Scientific IL-1 beta Polyclonal Antibody
IL-1 beta에 특이적인 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 50% glycerol 저장 버퍼를 사용합니다. 면역원은 IL-1 beta 단백질(aa 118–268)이며, 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rabbit |
| Host / Isotype | Guinea pig / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Interleukin 1 Beta (aa 118–268) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903717 |
Target Information
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires inflammasome activation, which processes caspase-1 into its active form. IL-1 beta lacks a signal sequence peptide for the classical ER/Golgi pathway and is secreted via an alternate mechanism. It signals through IL-1RI and IL-1RII receptors and its activity can be inhibited by IL-1 Receptor Antagonist (IL-1RA). Elevated IL-1 beta levels are associated with chronic inflammatory conditions, and neutralizing antibodies may have therapeutic potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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