Thermo Fisher Scientific MAPKAP1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
ATVQDMLSSH HYKSFKVSMI HRLRFTTDVQ LGISGDKVEI DPVTNQKAST KFWIKQKPIS IDSDLLCACD LAEEKSPSHA IFKLTYLSNH DYKHLYFESD AATVNEIVLK VNYILESRAS TARADYFAQK QRKLNRRTSF SFQKEKKSGQ

Target Information

Sin1 was initially identified as the human homolog of S. pombe SIN1. It is identical to Mip1, a protein interacting with MEKK2, a member of the MAPK intracellular signaling network. MAPKAP1 is thought to prevent MEKK2 activation and dimerization by forming a complex with inactive MEKK2, thereby blocking the JNK1/2, ERK1/2, p38, and ERK5 MAPKs.
MAPKAP1 also plays a role in the TOR signaling pathway, which regulates cell growth and proliferation in response to environmental cues such as nutrients, growth factors, and hormones. It helps maintain the TOR/rictor assembly but not the TOR/RAPTOR complex, allowing specific phosphorylation of Akt, linking the growth factor–PI3K signaling pathway to nutrient-regulated TOR signaling.
Multiple alternatively spliced isoforms of MAPKAP1 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.