Thermo Fisher Scientific MAPKAP1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human MAPKAP1. Validated for IHC(P) and ICC/IF applications. Supplied as a liquid, unconjugated form purified by antigen affinity chromatography. Suitable for research use in MAPK pathway and TOR signaling studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MAPKAP1 (amino acids 372–521). Recombinant protein control fragment available as Product #RP-89608. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790217 |
Product Specific Information
Immunogen sequence:
ATVQDMLSSH HYKSFKVSMI HRLRFTTDVQ LGISGDKVEI DPVTNQKAST KFWIKQKPIS IDSDLLCACD LAEEKSPSHA IFKLTYLSNH DYKHLYFESD AATVNEIVLK VNYILESRAS TARADYFAQK QRKLNRRTSF SFQKEKKSGQ
Target Information
Sin1 was initially identified as the human homolog of S. pombe SIN1. It is identical to Mip1, a protein interacting with MEKK2, a member of the MAPK intracellular signaling network. MAPKAP1 is thought to prevent MEKK2 activation and dimerization by forming a complex with inactive MEKK2, thereby blocking the JNK1/2, ERK1/2, p38, and ERK5 MAPKs.
MAPKAP1 also plays a role in the TOR signaling pathway, which regulates cell growth and proliferation in response to environmental cues such as nutrients, growth factors, and hormones. It helps maintain the TOR/rictor assembly but not the TOR/RAPTOR complex, allowing specific phosphorylation of Akt, linking the growth factor–PI3K signaling pathway to nutrient-regulated TOR signaling.
Multiple alternatively spliced isoforms of MAPKAP1 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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